Prolia is a medicine used to increase bone density and prevent bone fractures in patients with osteoporosis. It is given at a standard dose of 60 mg as an injection every 6 months at a doctor’s office or pharmacy. In people without osteoporosis bone is broken down to gather materials to build new bone; however, in patients with osteoporosis their bodies breakdown more bone than it rebuilds leading to more brittle bones. Prolia works by interfering with the bone remodeling process to decrease the break-down of bone.

Who should not use Prolia?
Prolia should not be used by people who have low levels of calcium in their body or by women that are pregnant.

What are the most common side effects?
Prolia may cause eczema or other non-severe skin rashes. Patients have also reported muscle and extremity pain and increase flatulence (or gas).

How much would this medication cost?
99% of patients with Medicare part D have access to Prolia through their insurance although copays and out-of-pocket costs may vary. Sunray Specialty and Sunray Drugs locations can administer Prolia at no additional cost to you.

Is Prolia right for me?
Prolia has similar side effects to other medicines used for osteoporosis but is more likely to cause skin rashes and gas. Other first choice options have very specific instructions and are taken by mouth once weekly. Prolia is given twice yearly by a healthcare professional. Talk to your doctor to find out Prolia is a good option to manage your osteoporosis.

Adapted from: Denosumab for the Treatment of Postmenopausal Osteoporosis. Presented as a webinar for the University of the Sciences course: Seminar in Professional Practice. Philadelphia, Pennsylvania. March 2020
By Jenna Januszka, PharmD Candidate 2021